Journal article

The enzymology of clavam and carbapenem biosynthesis.

Abstract:: The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and beta-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.

Publication status:: Published

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APA Style

Kershaw, N., Caines, M., Sleeman, M., & Schofield, C. (2005). The enzymology of clavam and carbapenem biosynthesis. Chemical Communications, 34, 4251–4263.

MLA Style

Kershaw, N., et al. “The Enzymology of Clavam and Carbapenem Biosynthesis.” Chemical Communications, no. 34, 2005, pp. 4251–63.

Chicago Style

Kershaw, N, M Caines, M Sleeman, and C Schofield. 2005. “The Enzymology of Clavam and Carbapenem Biosynthesis.” Chemical Communications, no. 34: 4251–63.
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Publisher copy:: 10.1039/b505964j

Authors

+ Kershaw, N More by this author

Role:: Author

+ Caines, M More by this author

Role:: Author

+ Sleeman, M More by this author

Role:: Author

+ Schofield, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Chemical Communications More from this journal
Issue:: 34
Pages:: 4251-4263
Publication date:: 2005-09-01
DOI:: 10.1039/b505964j
EISSN:: 1364-548X
ISSN:: 1359-7345

Language:: English
Keywords:: Models, Molecular

beta-Lactams

Indicators and Reagents

Clavulanic Acids

Enzymes

Molecular Conformation

Carbapenems

Oxidation-Reduction

Amino Acids
Pubs id:: pubs:33204
UUID:: uuid:280e6731-a9a8-463a-83d9-73c746f7c2a3
Local pid:: pubs:33204
Source identifiers:: 33204
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2005

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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