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The enzymology of clavam and carbapenem biosynthesis.

Abstract:
The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and beta-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.
Publication status:
Published

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Publisher copy:
10.1039/b505964j

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Communications More from this journal
Issue:
34
Pages:
4251-4263
Publication date:
2005-09-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Language:
English
Keywords:
Pubs id:
pubs:33204
UUID:
uuid:280e6731-a9a8-463a-83d9-73c746f7c2a3
Local pid:
pubs:33204
Source identifiers:
33204
Deposit date:
2012-12-19

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