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PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.

Abstract:

Posttranslational modification of chromatin by histone methylation has wide-ranging effects on nuclear function, including transcriptional regulation, maintenance of genome integrity, and epigenetic inheritance. The enzymes utilized to place histone methylation marks are well characterized, but the identity of a histone demethylation system remained elusive until recently. The discovery of histone demethylase enzymes capable of directly removing methyl groups from modified lysine residues has...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Molecular cell
Volume:
25
Issue:
6
Pages:
801-812
Publication date:
2007-03-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:28090497-93d2-44b3-a0f7-c7233f307fbb
Source identifiers:
99879
Local pid:
pubs:99879

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