- Abstract:
-
Posttranslational modification of chromatin by histone methylation has wide-ranging effects on nuclear function, including transcriptional regulation, maintenance of genome integrity, and epigenetic inheritance. The enzymes utilized to place histone methylation marks are well characterized, but the identity of a histone demethylation system remained elusive until recently. The discovery of histone demethylase enzymes capable of directly removing methyl groups from modified lysine residues has...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.molcel.2007.03.001
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- Journal:
- Molecular cell
- Volume:
- 25
- Issue:
- 6
- Pages:
- 801-812
- Publication date:
- 2007-03-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:28090497-93d2-44b3-a0f7-c7233f307fbb
- Source identifiers:
-
99879
- Local pid:
- pubs:99879
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.
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