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Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.

Abstract:

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke. We hypothesized that studying the molecular determinants of endogenous neuroprotection in two well-established paradigms, the resistance of CA3 hippocampal neurons to global ischemia and the tolerance conferred by ischemic preconditioning (IPC), would reveal new neuroprotective targets. We found tha...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nm.3097

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Xilouri, M More by this author
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Dunhill Medical Trust More from this funder
Fondation Leducq More from this funder
Oxford University Clinical Academic Graduate School More from this funder
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Journal:
Nat Med Journal website
Volume:
19
Issue:
3
Pages:
351-357
Publication date:
2013-03-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:27f7e68a-00df-4471-b6a3-2ea0a2d177c1
Source identifiers:
387088
Local pid:
pubs:387088

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