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Pax6 is required for the normal development of the forebrain axonal connections

Abstract:

The transcription factor PAX6 has been implicated in forebrain patterning, cerebral cortical arealization and in development of thalamocortical connections. Using a Pax6/lacZ knockout mouse, in which the endogenous Pax6 expression is reflected by b-galactosidase activity, we have studied the consequences of the loss of Pax6 function on thalamocortical (TCA) and corticofugal axon (CFA) pathfinding during the period of embryonic day (E) 14.5 to E18.5. Carbocyanine dye tracing in Pax6 heterozygo...

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Files:
  • (pdf, 996.8kb)
Journal:
Development
Publication date:
2002
Local pid:
ora:837
Subjects:

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