Journal article icon

Journal article

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.

Abstract:

Ovarian cancers migrate and metastasize over the surface of the peritoneal cavity. Consequently, dysregulation of mechanisms that limit cell migration may be particularly important in the pathogenesis of the disease. ARHI is an imprinted tumor-suppressor gene that is downregulated in >60% of ovarian cancers, and its loss is associated with decreased progression-free survival. ARHI encodes a 26-kDa GTPase with homology to Ras. In contrast to Ras, ARHI inhibits cell growth, but whether it al...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/onc.2011.213

Authors


Badgwell, DB More by this author
Expand authors...
Journal:
Oncogene
Volume:
31
Issue:
1
Pages:
68-79
Publication date:
2012-01-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:27c7d59c-28c6-493e-9273-d14f3bcafc64
Source identifiers:
314994
Local pid:
pubs:314994

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP