Journal article
Congenital Zika syndrome is associated with maternal protein malnutrition.
- Abstract:
- Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS.
- Publication status:
- Published
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(Preview, Version of record, 2.6MB, Terms of use)
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- Publisher copy:
- 10.1126/sciadv.aaw6284
Authors
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science Advances More from this journal
- Volume:
- 6
- Issue:
- 2
- Article number:
- eaaw6284
- Publication date:
- 2020-01-10
- Acceptance date:
- 2019-10-22
- DOI:
- EISSN:
-
2375-2548
- ISSN:
-
2375-2548
- Pmid:
-
31950075
- Language:
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English
- Pubs id:
-
1083931
- Local pid:
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pubs:1083931
- Deposit date:
-
2020-04-02
Terms of use
- Copyright holder:
- Barbeito-Andres et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
- Licence:
- CC Attribution-NonCommercial (CC BY-NC)
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