Journal article icon

Journal article

Insights about clonal hematopoiesis from 8,342 mosaic chromosomal alterations

Abstract:

The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations (mCAs) of length 50kb–249Mb that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using new phase-based computational techniques (estimated false discovery rate, 6–9%). We found six loci at which inherited variants associated strongly with the acquisition of deletions or loss of heterozygosity in cis. At three such loci ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-018-0321-x

Authors


Genovese, G More by this author
Handsaker, R More by this author
Finucane, H More by this author
Expand authors...
Burroughs Wellcome Fund More from this funder
Next Generation Fund More from this funder
Stanley Center for Psychiatric Research More from this funder
Fannie and John Hertz Foundation More from this funder
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
559
Issue:
7713
Pages:
350–355
Publication date:
2018-07-11
Acceptance date:
2018-05-16
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:868027
URN:
uri:27b822a0-d3ca-42be-854d-935173305101
UUID:
uuid:27b822a0-d3ca-42be-854d-935173305101
Local pid:
pubs:868027

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP