Journal article
Insights about clonal hematopoiesis from 8,342 mosaic chromosomal alterations
- Abstract:
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The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations (mCAs) of length 50kb–249Mb that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using new phase-based computational techniques (estimated false discovery rate, 6–9%). We found six loci at which inherited variants associated strongly with the acquisition of deletions or loss of heterozygosity in cis. At three such loci ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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(pdf, 327.4KB)
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- Publisher copy:
- 10.1038/s41586-018-0321-x
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Authors
Funding
Burroughs Wellcome Fund
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Next Generation Fund
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Stanley Center for Psychiatric Research
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Fannie and John Hertz Foundation
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 559
- Issue:
- 7713
- Pages:
- 350–355
- Publication date:
- 2018-07-11
- Acceptance date:
- 2018-05-16
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
- Pubs id:
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pubs:868027
- URN:
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uri:27b822a0-d3ca-42be-854d-935173305101
- UUID:
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uuid:27b822a0-d3ca-42be-854d-935173305101
- Local pid:
- pubs:868027
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2018
- Notes:
- © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/s41586-018-0321-x
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