Preprint
HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells
- Abstract:
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Background Cholesterol-loading of mouse aortic vascular smooth muscle cells (mVSMCs) downregulates miR-143/145, a master regulator of the contractile state downstream of TGFβ signaling. In vitro, this results in transitioning from a contractile mVSMC to a macrophage-like state. This process likely occurs in vivo based on studies in mouse and human atherosclerotic plaques.
Objectives To test whether cholesterol-loading red...
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- Publication status:
- Published
- Peer review status:
- Not peer reviewed
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- Files:
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(Preview, Pre-print, pdf, 2.2MB, Terms of use)
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- Preprint server copy:
- 10.1101/2023.10.19.562786
Authors
+ British Heart Foundation
More from this funder
- Funder identifier:
- https://ror.org/02wdwnk04
- Grant:
- FS/IBSRF/22/25110
- PG/18/53/33895
- RE/13/1/30181
+ National Heart Lung and Blood Institute
More from this funder
- Funder identifier:
- https://ror.org/012pb6c26
- Preprint server:
- bioRxiv
- Place of publication:
- United States
- Publication date:
- 2023-10-19
- DOI:
- EISSN:
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2692-8205
- Pmid:
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37905061
- Language:
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English
- Pubs id:
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1560366
- Local pid:
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pubs:1560366
- Deposit date:
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2026-03-11
- ARK identifier:
Terms of use
- Copyright holder:
- Nagesh et al
- Copyright date:
- 2023
- Rights statement:
- ©2023 The Authors. The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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