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Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber

Abstract:

Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1,2,3,4. Advances in wavefront-shaping methods and computational power have recently allowed for a novel approach to high-resolution imaging, utilizing deterministic light propagation through optically complex media and, of particular importance for this work, multimode optical fibers (MMFs)5...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41377-018-0111-0

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
Ploschner, M More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Funding agency for:
Vasquez-Lopez, S
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Funding agency for:
Vasquez-Lopez, S
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Funding agency for:
Turcotte, R
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Publisher:
Springer Nature Publisher's website
Journal:
Light: Science and Applications Journal website
Volume:
7
Pages:
Article: 110
Publication date:
2018-12-19
Acceptance date:
2018-12-03
DOI:
EISSN:
2047-7538
ISSN:
2095-5545
Pubs id:
pubs:948546
URN:
uri:2795ae3f-48b3-4f12-a78c-7072d12f8db1
UUID:
uuid:2795ae3f-48b3-4f12-a78c-7072d12f8db1
Local pid:
pubs:948546

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