Journal article
Case report: intrahepatic cholestasis: a diagnostic dilemma
- Abstract:
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Cholestasis is an impairment of bile formation or bile flow. The mechanisms of cholestasis can be broadly classified into intrahepatic and extrahepatic. Most of the time, etiology can be determined with proper history, physical examination, and diagnostic testing including laboratory and imaging tests. This is a case report of a patient with severe cholestasis who underwent extensive evaluation to determine the etiology of intrahepatic cholestasis.
This Case Report details a 28-year-old male who presented with seven days’ history of yellowish discoloration of eyes, the passage of dark-colored urine, generalized body itching, and the passage of clay-colored stool. The patient had no similar episode in the past. Laboratory investigations showed unconjugated hyperbilirubinemia and increased alkaline phosphatase. Magnetic resonance cholangiopancreaticography was unremarkable and liver biopsy was suggestive of cholestatic pattern and negative for acute hepatitis. The bilirubin level started decreasing after a month.
The etiology of intrahepatic cholestasis remained unknown. Genotyping could not be done due to limited available resources. It may have helped to diagnose familial hepatocellular cholestasis such as benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis. Gamma-glutamyl transferase is normal or mildly elevated in patients with BRIC. A similar picture was seen in our case as well. If the patient presents again with similar symptoms and findings, we can consider the diagnosis of BRIC.
- Publication status:
- Published
- Peer review status:
- Under review
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- Files:
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(Preview, Version of record, pdf, 1014.8KB, Terms of use)
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- Publisher copy:
- 10.12688/wellcomeopenres.19381.2
Authors
- Publisher:
- Taylor and Francis
- Journal:
- Wellcome Open Research More from this journal
- Volume:
- 8
- Article number:
- 226
- Publication date:
- 2023-05-24
- DOI:
- EISSN:
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2398-502X
- ISSN:
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2398-502X
- Pmid:
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39600379
- Language:
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English
- Keywords:
- Pubs id:
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2070854
- Local pid:
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pubs:2070854
- Deposit date:
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2025-02-14
- ARK identifier:
Terms of use
- Copyright holder:
- Acharya et al.
- Copyright date:
- 2024
- Rights statement:
- © 2024 Acharya U et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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