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Journal article

Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome, and serum testosterone.

Abstract:

CYP11A, the gene encoding p450scc, a key enzyme in steroid biosynthesis, is a strong biological candidate for polycystic ovary syndrome (PCOS) susceptibility. Four of the five published studies that have examined CYP11A for evidence of linkage and/or association have reported significant relationships with polycystic ovary (PCO) status and/or serum testosterone levels. However, study sizes have been modest, and the current study aimed to reevaluate these findings using significantly larger cl...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2003-031640

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
89
Issue:
5
Pages:
2408-2413
Publication date:
2004-05-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:27906223-b70f-4e13-ada6-15cfa5aa1b62
Source identifiers:
7691
Local pid:
pubs:7691

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