Journal article
Sulfinamide synthesis using organometallic reagents, DABSO, and amines
- Abstract:
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We report the synthesis of sulfinamides using organometallic reagents, a sulfur dioxide reagent, and nitrogen based-nucleophiles. The addition of an organometallic reagent to the commercially available sulfur dioxide surrogate, DABSO, generates a metal sulfinate which is reacted with thionyl chloride to form a sulfinyl chloride intermediate. Trapping the sulfinyl chlorides in situ with a variety of nitrogen nucleophiles delivers sulfinamides in 32–83% yields. Each stage of the process is perf...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.joc.0c00334
Authors
Funding
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Organic Chemistry More from this journal
- Volume:
- 85
- Issue:
- 9
- Pages:
- 5753-5760
- Publication date:
- 2020-04-14
- Acceptance date:
- 2020-04-06
- DOI:
- EISSN:
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1520-6904
- ISSN:
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0022-3263
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1098991
- Local pid:
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pubs:1098991
- Deposit date:
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2020-04-07
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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