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Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis.

Abstract:

An open, paired, randomized, controlled trial of high-dose parenteral ceftazidime (120 mg/[kg.d]) vs. amoxicillin/clavulanate (160 mg/[kg.d]) for the treatment of severe melioidosis was conducted in Ubon Ratchatani in northeastern Thailand. Of 379 patients enrolled in the study, 212 (56%) had culture-proven melioidosis; 106 patients were in each treatment group. The overall mortality rate (47%) was similar for both treatment groups. However, 4 of 75 surviving patients in the ceftazidime group...

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Publication status:
Published

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Publisher copy:
10.1093/clinids/19.5.846

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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
19
Issue:
5
Pages:
846-853
Publication date:
1994-11-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:274e3877-e3a1-4d29-90ff-9612ed4ab50b
Source identifiers:
44639
Local pid:
pubs:44639

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