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On a novel rate theory for transport in narrow ion channels and its application to the study of flux optimization via geometric effects.

Abstract:

We present a novel rate theory based on the notions of splitting probability and mean first passage time to describe single-ion conduction in narrow, effectively one-dimensional membrane channels. In contrast to traditional approaches such as transition state theory or Kramers theory, transitions between different conduction states in our model are governed by rates which depend on the full geometry of the potential of mean force (PMF) resulting from the superposition of an equilibrium free e...

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Publication status:
Published

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Publisher copy:
10.1063/1.3077205

Authors


Reingruber, J More by this author
Sansom, MS More by this author
Journal:
The Journal of chemical physics
Volume:
130
Issue:
8
Pages:
085101
Publication date:
2009-02-05
DOI:
EISSN:
1089-7690
ISSN:
0021-9606
URN:
uuid:2741969c-47c3-43c0-bfa5-e54bc6c22b0a
Source identifiers:
100610
Local pid:
pubs:100610

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