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YACs, BACs, PACs and MACs: artificial chromosomes as research tools.

Abstract:
Yeast artificial chromosomes (YACs) have become essential research tools as they enable large fragments of DNA to be cloned. In order to overcome several disadvantages of YACs, including chimaerism and instability, several complementary bacterial artificial chromosome (BAC) vectors have been developed. More recently, attempts are being made to construct artificial chromosomes in mammalian cells (MACs).
Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Publisher:
Elsevier
Journal:
Trends in biotechnology
Volume:
12
Issue:
7
Pages:
280-286
Publication date:
1994-07-01
DOI:
EISSN:
1879-3096
ISSN:
0167-7799
Source identifiers:
35695
Language:
English
Keywords:
Pubs id:
pubs:35695
UUID:
uuid:273c7b3b-6c1a-4025-ad94-f2479def2160
Local pid:
pubs:35695
Deposit date:
2012-12-19

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