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YACs, BACs, PACs and MACs: artificial chromosomes as research tools.

Abstract:
Yeast artificial chromosomes (YACs) have become essential research tools as they enable large fragments of DNA to be cloned. In order to overcome several disadvantages of YACs, including chimaerism and instability, several complementary bacterial artificial chromosome (BAC) vectors have been developed. More recently, attempts are being made to construct artificial chromosomes in mammalian cells (MACs).
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Publisher:
Elsevier Applied Science Publ Ltd
Journal:
Trends in biotechnology
Volume:
12
Issue:
7
Pages:
280-286
Publication date:
1994-07-05
DOI:
EISSN:
1879-3096
ISSN:
0167-7799
URN:
uuid:273c7b3b-6c1a-4025-ad94-f2479def2160
Source identifiers:
35695
Local pid:
pubs:35695

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