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Thesis

The spatio-temporal regulation of Polo-like kinase 1 in DNA repair

Abstract:

The G2/M cell cycle kinase Polo-like kinase 1 (PLK1) was recently discovered to play an active role in DNA repair by phosphorylating the RAD51 recombinase to aid homologous recombination. This occurs at a much shorter timeframe than the well-characterised downregulation of PLK1 activity via the DNA damage checkpoint. In this thesis, I expand upon this by investigating the regulation of PLK1 during this earlier timeframe post-damage. Laser microirradiation experiments observe fluorescently-...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:2723d8e9-4a0d-4202-9b2b-ec218c704695
Deposit date:
2019-06-21

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