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A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol: Two meta-analyses and a meta-regression analysis

Abstract:

Background: We sought to determine if a common polymorphism can influence vulnerability to LDL cholesterol, and thereby influence the clinical benefit derived from therapies that reduce LDL cholesterol. Methods: We conducted a meta-analysis of the association between a common Trp719Arg polymorphism in the kinesin-like protein 6 (KIF6) gene and the risk of cardiovascular disease (CVD), and a meta-regression analysis to measure the effect modification of this polymorphism on the association bet...

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Publisher copy:
10.1371/journal.pone.0028834

Authors


Ference, BA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Journal:
PLoS ONE
Volume:
6
Issue:
12
Publication date:
2011-12-21
DOI:
EISSN:
1932-6203
URN:
uuid:27157570-0bc6-450f-abbc-7f59f3628555
Source identifiers:
239755
Local pid:
pubs:239755
Language:
English

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