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Amphiphilic DNA tiles for controlled insertion and 2D assembly on fluid lipid membranes: Effect on mechanical properties

Abstract:

Future lipid membrane-associated DNA nanostructures are expected to find applications ranging from synthetic biology to nanomedicine. Here we have designed and synthesized DNA tiles and modified them by amphiphilic covalent moieties. dod-DEG groups, which consist of a hydrophilic diethylene glycol (DEG) and a hydrophobic dodecyl group, are introduced at the phosphate backbone to create amphiphilic DNA strands which are subsequently introduced into one face of DNA tiles. In this way the tile b...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Files:
Publisher copy:
10.1039/C6NR07084A

Authors


Makishi, S More by this author
Nakatani, K More by this author
More by this author
Department:
Green Templeton College
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Nanoscale Journal website
Volume:
9
Issue:
9
Pages:
3051-3058
Publication date:
2017-01-27
Acceptance date:
2017-01-27
DOI:
EISSN:
2040-3372
ISSN:
2040-3364
Pubs id:
pubs:673518
URN:
uri:26c72cbd-e29d-48a2-9a88-764ea171329c
UUID:
uuid:26c72cbd-e29d-48a2-9a88-764ea171329c
Local pid:
pubs:673518

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