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Human immunodeficiency virus infection impairs Th1 and Th17 Mycobacterium tuberculosis–specific T-cell responses

Abstract:

Human immunodeficiency virus (HIV)-infected individuals have a higher risk of developing active tuberculosis (TB) than HIV-uninfected individuals, but the mechanisms underpinning this are unclear. We hypothesized that depletion of specific components of Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T-cell responses contributed to this increased risk.Mtb-specific T-cell responses in 147 HIV-infected and 44 HIV-uninfected control subjects in a TB-endemic setting in Bloemfontein, South...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jiy052

Authors


Murray, LW More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
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Grant:
Scholarship award (to L. M.)
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
217
Issue:
11
Pages:
1782–1792
Publication date:
2018-03-13
Acceptance date:
2018-03-09
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:830325
URN:
uri:269cb154-e327-4fce-b976-de2e12ec981e
UUID:
uuid:269cb154-e327-4fce-b976-de2e12ec981e
Local pid:
pubs:830325

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