Journal article
Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications
- Abstract:
- Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at least in many tumour types, plays a critical role in delivering the bioenergetic and macromolecular anabolic requirements of cancer cells. There is now great interest in targeting the OXPHOS and the electron transport chain for cancer therapy and in this review article we describe current therapeutic approaches and challenges.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1016/j.semcancer.2022.02.002
Authors
- Publisher:
- Elsevier
- Journal:
- Seminars in Cancer Biology More from this journal
- Volume:
- 86
- Issue:
- Part 2
- Pages:
- 851-859
- Publication date:
- 2022-02-03
- Acceptance date:
- 2022-02-01
- DOI:
- EISSN:
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1096-3650
- ISSN:
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1044-579X
- Pmid:
-
35122973
- Language:
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English
- Keywords:
- Pubs id:
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1241089
- Local pid:
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pubs:1241089
- Deposit date:
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2022-05-10
- ARK identifier:
Terms of use
- Copyright holder:
- Greene et al
- Copyright date:
- 2022
- Rights statement:
- ©2022 The Authors. Published by Elsevier Ltd. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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