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Journal article

Thrombomodulation via CLEC-2 targeting.

Abstract:

CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and aggregation. The snake venom protein rhodocytin and the endogenous protein podoplanin have been identified as ligands. The structures of CLEC-2 and rhodocytin suggest that ligand bi...

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Publication status:
Published

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Publisher copy:
10.1016/j.coph.2008.11.001

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
Journal:
Current opinion in pharmacology
Volume:
9
Issue:
2
Pages:
90-95
Publication date:
2009-04-05
DOI:
EISSN:
1471-4973
ISSN:
1471-4892
URN:
uuid:26835bd4-3ed2-49bc-8285-91910fa37daf
Source identifiers:
19700
Local pid:
pubs:19700

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