Journal article icon

Journal article

Thrombomodulation via CLEC-2 targeting.

Abstract:

CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and aggregation. The snake venom protein rhodocytin and the endogenous protein podoplanin have been identified as ligands. The structures of CLEC-2 and rhodocytin suggest that ligand bi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.coph.2008.11.001

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Current opinion in pharmacology
Volume:
9
Issue:
2
Pages:
90-95
Publication date:
2009-04-01
DOI:
EISSN:
1471-4973
ISSN:
1471-4892
Source identifiers:
19700
Language:
English
Keywords:
Pubs id:
pubs:19700
UUID:
uuid:26835bd4-3ed2-49bc-8285-91910fa37daf
Local pid:
pubs:19700
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP