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Journal article

The biochemistry and immunology of non-canonical forms of HLA-B27

Abstract:

HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 is expressed at the cell surface of antigen presenting cells (APC) both as canonical β2m-associated and non-canonical β2m-free heavy chain (FHC) forms which include B27 dimers (termed B272). B27 FHC forms arise in an endosomal compartment from recycling β2m-associated B27. Formation of cell surface FHC dimers is critically dependent on an unpaired reactive cysteine 67 in the α1 helix of the class I heavy chain. HLA-B27 als...

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Journal:
Molecular Immunology
Volume:
57
Issue:
1
Pages:
52-58
Publication date:
2014-01-05
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
URN:
uuid:267a6540-441c-425d-8ed7-7ce12c7240a3
Source identifiers:
432602
Local pid:
pubs:432602

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