Pharmacokinetics of zidovudine dosed twice daily according to World Health Organization weight bands in Ugandan HIV-infected children.

Journal article

Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.

Authors: Fillekes, Q; Kendall, L; Kitaka, S; Mugyenyi, P; Musoke, P

• Publication status: Published
• Journal: Pediatric infectious disease journal
• Volume: 33
• Issue: 5
• Pages: 495-498
• Publication date: 2014-05-01
• DOI: 10.1097/INF.0000000000000143
• EISSN: 1532-0987
• ISSN: 0891-3668
• Language: English
• Keywords: Female; Humans; Hemoglobins; Guidelines as Topic; World Health Organization; Child, Preschool; Uganda; Infant; ARROW Trial Team; Child; Body Weight; Cross-Over Studies; Male; Area Under Curve; Plasma; Zidovudine; HIV Infections; Anti-HIV Agents