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Pharmacokinetics of zidovudine dosed twice daily according to World Health Organization weight bands in Ugandan HIV-infected children.

Abstract:
Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.
Publication status:
Published

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Authors


Fillekes, Q More by this author
Kendall, L More by this author
Mugyenyi, P More by this author
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Journal:
The Pediatric infectious disease journal
Volume:
33
Issue:
5
Pages:
495-498
Publication date:
2014-05-05
DOI:
EISSN:
1532-0987
ISSN:
0891-3668
URN:
uuid:26726057-ab5d-4051-b415-1bd2143a78c9
Source identifiers:
463428
Local pid:
pubs:463428

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