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Journal article

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

Abstract:

The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1beta and BS69, and localizes to sites of repair following DNA damage. EMSY maps to chromosome 11q13.5, a region known to be involved in breast and ov...

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Publication status:
Published

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Authors


Hughes-Davies, L More by this author
Huntsman, D More by this author
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Journal:
Cell
Volume:
115
Issue:
5
Pages:
523-535
Publication date:
2003-11-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:266f243b-93aa-47b4-bd4b-a7f7c4251c83
Source identifiers:
101288
Local pid:
pubs:101288

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