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Zebrafish mesonephric renin cells are functionally conserved and comprise of two distinct morphological populations

Abstract:

Zebrafish provide an excellent model in which to assess the role of the renin-angiotensin system in renal development, injury and repair. In contrast to mammals, zebrafish kidney organogenesis terminates with the mesonephros. Despite this, the basic functional structure of the nephron is conserved across vertebrates. The relevance of teleosts for studies relating to the regulation of the renin-angiotensin system was established by assessing the phenotype and functional regulation of renin-exp...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1152/ajprenal.00608.2016

Authors


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Institution:
University of Oxford
Department:
St Annes College
Mullins, LJ More by this author
Howarth, AR More by this author
MacRae, CA More by this author
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Grant:
Centre of Research Excellence
Kidney Research UK More from this funder
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Grant:
Zebrafish facility
Publisher:
American Physiological Society Publisher's website
Journal:
AJP - Renal Physiology Journal website
Volume:
312
Issue:
4
Pages:
F778-F790
Publication date:
2017-02-08
Acceptance date:
2017-02-01
DOI:
EISSN:
1522-1466
ISSN:
1931-857X
Pubs id:
pubs:679617
URN:
uri:266c93f6-a8e9-4aee-817e-75eba05cd3ef
UUID:
uuid:266c93f6-a8e9-4aee-817e-75eba05cd3ef
Local pid:
pubs:679617

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