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Journal article

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.

Abstract:

BACKGROUND: New tuberculosis (TB) vaccines are being developed to combat the global epidemic. A phase IIb trial of a candidate vaccine, MVA85A, was conducted in a high burden setting in South Africa to evaluate proof-of-concept efficacy for prevention of TB in infants. OBJECTIVE: To describe the study design and implementation lessons from an infant TB vaccine efficacy trial. METHODS: This was a randomised, controlled, double-blind clinical trial comparing the safety and efficacy of MVA85A to...

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Publication status:
Published

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Publisher copy:
10.1016/j.tube.2013.01.003

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Tuberculosis (Edinburgh, Scotland)
Volume:
93
Issue:
2
Pages:
143-149
Publication date:
2013-03-05
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
URN:
uuid:2648af1b-0b50-48fb-b915-476a107088e5
Source identifiers:
384752
Local pid:
pubs:384752

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