- Abstract:
- The syntheses of 1,4-dideoxy-1,4-imino-D-lyxitol (3), 1,4-dideoxy-1,4-imino-d-arabinitol (4) and 1,4-dideoxy-1,4-imino-l-arabinitol (5) are reported; (3) is a potent competitive inhibitor of α-galactosidase (green coffee beans) and (4) a competitive inhibitor of α-glucosidase (Brewer's yeast) suggesting that iminopentitols have considerable potential as glycosidase inhibitors. (4) was found to be identical to an alkaloid recently isolated from Angylocalyx boutiqueanus. © 1985.
- Publication status:
- Published
- Publisher copy:
- 10.1016/S0040-4039(00)98636-2
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- Journal:
- TETRAHEDRON LETTERS
- Volume:
- 26
- Issue:
- 26
- Pages:
- 3127-3130
- Publication date:
- 1985-01-01
- DOI:
- ISSN:
-
0040-4039
- URN:
-
uuid:25fae2e8-9a20-4f33-a81f-47c0fe104806
- Source identifiers:
-
42511
- Local pid:
- pubs:42511
- Language:
- English
- Copyright date:
- 1985
Journal article
POTENT COMPETITIVE-INHIBITION OF ALPHA-GALACTOSIDASE AND ALPHA-GLUCOSIDASE ACTIVITY BY 1,4-DIDEOXY-1,4-IMINOPENTITOLS - SYNTHESES OF 1,4-DIDEOXY-1,4-IMINO-D-LYXITOL AND OF BOTH ENANTIOMERS OF 1,4-DIDEOXY-1,4-IMINOARABINITOL
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