The nuclear envelope and its involvement in cellular stress responses.

Journal article

Abstract:: The nuclear envelope is not only important for the structural integrity of the nucleus, but also involved in a number of cellular functions. It has been shown to be important for maintaining and controlling chromatin organization, sequestering transcription factors, replication, transcription and signalling. The nuclear envelope is thus important for development and differentiation, and some of its components are essential for cell viability. Among the many functions which are emerging for the nuclear envelope is its involvement in protecting the cell against different types of cellular stress. In the present paper, we review key findings which describe the roles of nuclear envelope components in responses to common types of stress conditions.

Files:: Biochem Soc Trans (2011) Vol 39 p00.pdf

(Preview, Accepted manuscript, pdf, 324.4KB, Terms of use)

Language:: English
Keywords:: Animals

Heat-Shock Response

Stress, Physiological

Nuclear Envelope

Oxidative Stress

DNA Damage

Humans

Osmotic Pressure
Pubs id:: pubs:205979
UUID:: uuid:25e5ce69-5f6d-4ddc-a31d-06b54234327b
Local pid:: pubs:205979
Source identifiers:: 205979
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_25e5ce695f6d4ddca31d06b54234327b

Copyright holder:: Biochemical Society
Notes:: This research was originally published in Biochemical Society Transactions. Ashraf N. Malhas and David J. Vaux, "The nuclear envelope and its involvement in cellular stress responses". Biochemical Society Transactions. 2011; 39: 1795-1798. Copyright the Biochemical Society.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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