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Journal article

Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes.

Abstract:

Nucleotide insertion and deletion (indel) events, together with substitutions, represent the major mutational processes of gene evolution. Through the alignment of 8148 orthologous genes from human, mouse, and rat, we have identified 1743 indel events within rodent protein-coding sequences. Using human as an out-group, we reconstructed the mutational event underlying each of these indels. Overall, we found an excess of deletions over insertions, particularly for the rat lineage (70% excess). ...

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Publication status:
Published

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Publisher copy:
10.1101/gr.1977804

Authors


Taylor, MS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Journal:
Genome research
Volume:
14
Issue:
4
Pages:
555-566
Publication date:
2004-04-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:25cdf4fe-f757-449b-8cba-c10d77d0730d
Source identifiers:
54034
Local pid:
pubs:54034

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