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Journal article

Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes.

Abstract:

Nucleotide insertion and deletion (indel) events, together with substitutions, represent the major mutational processes of gene evolution. Through the alignment of 8148 orthologous genes from human, mouse, and rat, we have identified 1743 indel events within rodent protein-coding sequences. Using human as an out-group, we reconstructed the mutational event underlying each of these indels. Overall, we found an excess of deletions over insertions, particularly for the rat lineage (70% excess). ...

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Publication status:
Published

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Publisher copy:
10.1101/gr.1977804

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Genome research
Volume:
14
Issue:
4
Pages:
555-566
Publication date:
2004-04-01
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Source identifiers:
54034
Language:
English
Keywords:
Pubs id:
pubs:54034
UUID:
uuid:25cdf4fe-f757-449b-8cba-c10d77d0730d
Local pid:
pubs:54034
Deposit date:
2012-12-19

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