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A mouse model for Down syndrome exhibits learning and behaviour deficits.

Abstract:

Trisomy 21 or Down syndrome (DS) is the most frequent genetic cause of mental retardation, affecting one in 800 live born human beings. Mice with segmental trisomy 16 (Ts65Dn mice) are at dosage imbalance for genes corresponding to those on human chromosome 21q21-22.3--which includes the so-called DS 'critical region'. They do not show early-onset of Alzheimer disease pathology; however, Ts65Dn mice do demonstrate impaired performance in a complex learning task requiring the integration of vi...

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Publication status:
Published

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Publisher copy:
10.1038/ng1095-177

Authors


Reeves, RH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Nature genetics
Volume:
11
Issue:
2
Pages:
177-184
Publication date:
1995-10-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:25bd558e-7dd4-4e44-8810-6e3241c7ae32
Source identifiers:
440036
Local pid:
pubs:440036

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