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Microsatellite instability in early onset and familial colorectal cancer.

Abstract:

Hereditary non-polyposis colorectal cancer syndrome (HNPCC) is often considered to be the most common form of inherited colorectal cancer, although its precise incidence is unknown. The clinical diagnosis of HNPCC relies on a combination of family history and young age of onset of colorectal cancer, but as many familial aggregations of colorectal cancer do not fulfil the strict diagnostic criteria, HNPCC might be underdiagnosed. The majority of HNPCC families have germline mutations in mismat...

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Publisher copy:
10.1136/jmg.33.12.981

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Journal of medical genetics
Volume:
33
Issue:
12
Pages:
981-985
Publication date:
1996-12-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:259afda3-16e7-4b15-884c-129cc915aaab
Source identifiers:
373897
Local pid:
pubs:373897

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