Journal article
Schistosoma mansoni infection risk for school-aged children clusters within households and is modified by distance to freshwater bodies
- Abstract:
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Background
The interaction of socio-demographic and ecological factors with Schistosoma mansoni (S. mansoni) infection risk by age and the household clustering of infections between individuals are poorly understood.Methods
This study examined 1,832 individuals aged 5–90 years across 916 households in Mayuge District, Uganda. S. mansoni infection status and intensity were measured using Kato-Katz microscopy. Socio-demographic and ecological factors were examined as predictors of infection status and intensity using logistic and negative binomial regression models, respectively, with standard errors clustered by household. A subgroup analysis of children was conducted to examine the correlation of infection status between children and their caretakers.Findings
Infection varied within age groups based on the distance to Lake Victoria. Children aged 9–17 years and young adults aged 18–29 years who lived ≤0.50km from Lake Victoria were more likely to be infected compared to individuals of the same age who lived further away from the lake. Infections clustered within households. Children whose caretakers were heavily infected were 2.67 times more likely to be infected.Conclusion
These findings demonstrate the focality of schistosome transmission and its dependence on socio-demographic, ecological and household factors. Future research should investigate the sampling of households within communities as a means of progressing towards precision mapping of S. mansoni infections.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0258915
Authors
+ Wellcome Trust Institutional Strategic Support Fund
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- Funding agency for:
- Chami, GF
- Grant:
- 204826/Z/16/Z
+ University of Cambridge Vice Chancellor’s Fund
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- Funding agency for:
- Chami, GF
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 16
- Issue:
- 11
- Article number:
- e0258915
- Publication date:
- 2021-11-04
- Acceptance date:
- 2021-10-07
- DOI:
- EISSN:
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1932-6203
- Language:
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English
- Keywords:
- Pubs id:
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1200228
- Local pid:
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pubs:1200228
- Deposit date:
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2021-10-12
Terms of use
- Copyright holder:
- Lamberti et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright: © 2021 Lamberti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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