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The role of DNA damage response proteins in innate immune signalling: a new role for BRCA1

Abstract:

Pattern Recognition Receptors (PRRs), which have evolved to detect a diverse array of pathogenic features known as Pathogen Associated Molecular Patterns (PAMPs), are localised optimally for interaction with their cognate ligands. Upon Receptor activation, signal transduction pathways are induced which converge at different points to direct a specific inflammatory response. TBK1 is activated and recruited to multiple PRRs, where it in turn recruits and phosphorylates IRF3 which then transloca...

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Department:
University of Oxford, MSD, NDM
Role:
Copyright Holder, Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English

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