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Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.

Abstract:

The -344 C/T and intron 2 conversion variants in the CYP11B2 gene, encoding aldosterone synthase, have been associated with markers of impaired 11beta-hydroxylase activity. We hypothesize that this association is because of variations in the adjacent 11beta-hydroxylase gene (CYP11B1) and arises through linkage disequilibrium between CYP11B1 and CYP11B2. The pattern of variation across the entire CYP11B locus was determined by sequencing 26 normotensive subjects stratified by and homozygous fo...

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Publication status:
Published

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Journal:
Hypertension
Volume:
49
Issue:
1
Pages:
113-119
Publication date:
2007-01-05
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
URN:
uuid:25106283-00eb-40e3-b132-60ba78b40fa4
Source identifiers:
105049
Local pid:
pubs:105049

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