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A single-chain immunotoxin against carcinoembryonic antigen that suppresses growth of colorectal carcinoma cells.

Abstract:

We have engineered an anti-carcinoembryonic antigen (CEA) single-chain immunotoxin derived from humanized anti-CEA antibody (hMN14) and a truncated Pseudomonas exotoxin (PE), PE40. The purified anti-CEA immunotoxin (hMN14(Fv)-PE40) was first measured for binding affinity against a CEA-positive colorectal carcinoma cell line and compared with its parental IgG and the monovalent Fab fragment. The Ka of sFv-PE40, Fab, and IgG were 5 x 10(7), 6 x 10(7), and 3 x 10(8) M(-1), respectively. There wa...

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Publication status:
Published

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Authors


Akamatsu, Y More by this author
Murphy, JC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Kreitman, RJ More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
4
Issue:
11
Pages:
2825-2832
Publication date:
1998-11-05
ISSN:
1078-0432
URN:
uuid:250f685d-c377-4c01-a9ee-3d822f2c5847
Source identifiers:
60633
Local pid:
pubs:60633

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