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Chloride channels in renal disease.

Abstract:

Recent studies of hereditary renal tubular disorders have facilitated the identification and roles of chloride channels and cotransporters in the regulation of the most abundant anion, Cl-, in the ECF. Thus, mutations that result in a loss of function of the voltage-gated chloride channel, CLC-5, are associated with Dent's disease, which is characterized by low-molecular weight proteinuria, hypercalciuria, nephrolithiasis, and renal failure. Mutations of another voltage-gated chloride channel...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Advances in nephrology from the Necker Hospital
Volume:
29
Pages:
289-298
Publication date:
1999
ISSN:
0084-5957
URN:
uuid:250d6139-be9e-4c58-b9c8-273a814503b2
Source identifiers:
30279
Local pid:
pubs:30279

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