Development of a novel anisotropic self-inflating tissue expander:  in vivo submucoperiosteal performance in the porcine hard palate.

Swan, M; Bucknall, D; Czernuszka, J; Pigott, D; Goodacre, T

Journal article

Development of a novel anisotropic self-inflating tissue expander: in vivo submucoperiosteal performance in the porcine hard palate.

Abstract:: BACKGROUND: The advent of self-inflating hydrogel tissue expanders heralded a significant advance in the reconstructive potential of this technique. Their use, however, is limited by their uncontrolled isotropic (i.e., uniform in all directions) expansion. METHODS: Anisotropy (i.e., directional dependence) was achieved by annealing a hydrogel copolymer of poly(methyl methacrylate-co-vinyl pyrrolidone) under a compressive load for a specified time period. The expansion ratio is dictated by the percentage of vinyl pyrrolidone content and the degree of compression. The expansion rate is modified by incorporating the polymer within a silicone membrane. The in vivo efficacy of differing prototype devices was investigated in juvenile pigs under United Kingdom Home Office Licence. The devices were implanted within a submucoperiosteal pocket in a total of six porcine palates; all were euthanized by 6 weeks after implantation. A longitudinal volumetric assessment of the expanded tissue was conducted, in addition to postmortem analysis of the bony and mucoperiosteal palatal elements. RESULTS: Uncoated devices caused excessive soft-tissue expansion that resulted in mucoperiosteal ulceration, thus necessitating animal euthanasia. The silicone-coated devices produced controlled soft-tissue expansion over the 6-week study period. There was a statistically significant increase in the volume of expanded soft tissue with no evidence of a significant acute inflammatory response to the implant, although peri-implant capsule formation was observed. Attenuation of the bony palatal shelf was noted. CONCLUSION: A unique anisotropic hydrogel device capable of controlled expansion has been developed that addresses a number of the shortcomings of the technology hitherto available.

Publication status:: Published

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APA Style

Swan, M., Bucknall, D., Czernuszka, J., Pigott, D., & Goodacre, T. (2012). Development of a novel anisotropic self-inflating tissue expander: in vivo submucoperiosteal performance in the porcine hard palate. Plastic and Reconstructive Surgery, 129(1), 79–88.

MLA Style

Swan, M., et al. “Development of a Novel Anisotropic Self-Inflating Tissue Expander: in Vivo Submucoperiosteal Performance in the Porcine Hard Palate.” Plastic and Reconstructive Surgery, vol. 129, no. 1, 2012, pp. 79–88.

Chicago Style

Swan, M, D Bucknall, J Czernuszka, D Pigott, and T Goodacre. 2012. “Development of a Novel Anisotropic Self-Inflating Tissue Expander: in Vivo Submucoperiosteal Performance in the Porcine Hard Palate.” Plastic and Reconstructive Surgery 129 (1): 79–88.
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