Journal article
Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane
- Abstract:
- Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.1MB, Terms of use)
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- Publisher copy:
- 10.1016/j.isci.2018.12.001
Authors
- Publisher:
- Cell Press
- Journal:
- iScience More from this journal
- Volume:
- 10
- Pages:
- 234–244
- Publication date:
- 2018-12-05
- Acceptance date:
- 2018-11-30
- DOI:
- EISSN:
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2589-0042
- Pubs id:
-
pubs:944447
- UUID:
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uuid:24e1ee65-91fb-45b9-aed6-d0c4cfd6c9aa
- Local pid:
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pubs:944447
- Source identifiers:
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944447
- Deposit date:
-
2018-11-20
- ARK identifier:
Terms of use
- Copyright holder:
- Taylor et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Author(s). This is an open access article under the CC BY licence
- Licence:
- CC Attribution (CC BY)
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