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Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane

Abstract:

Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is depend...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.isci.2018.12.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Lincoln College
Role:
Author
More from this funder
Funding agency for:
Emptage, N
Grant:
G0802613
Publisher:
Cell Press Publisher's website
Journal:
iScience Journal website
Volume:
10
Pages:
234–244
Publication date:
2018-12-05
Acceptance date:
2018-11-30
DOI:
EISSN:
2589-0042
Source identifiers:
944447
Pubs id:
pubs:944447
UUID:
uuid:24e1ee65-91fb-45b9-aed6-d0c4cfd6c9aa
Local pid:
pubs:944447
Deposit date:
2018-11-20

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