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Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton

Abstract:

Background: The genesis of the eukaryotes was a pivotal event in evolution and was accompanied by the acquisition of numerous new cellular features including compartmentalization by cytoplasmic organelles, mitosis and meiosis, and ciliary motility. Essential for the development of these features was the tubulin cytoskeleton and associated motors. It is therefore possible to map ancient cell evolution by reconstructing the evolutionary history of motor proteins. Here, we have used the kinesin ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2148-10-110

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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
Role:
Author
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Institution:
University of Exeter
Department:
Centre for Eukaryotic Evolutionary Microbiology,School of Biosciences
Role:
Author
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Funding agency for:
Bill Wickstead
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Funding agency for:
Keith Gull
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Funding agency for:
Thomas A. Richards
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Evolutionary Biology Journal website
Volume:
10
Pages:
Article: 110
Publication date:
2010-04-05
DOI:
ISSN:
1471-2148
URN:
uuid:24deed16-cacf-4e63-883a-c5f30fd55cc8
Local pid:
ora:4102
Language:
English
Subjects:

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