- Abstract:
-
We present two comparative models of the GABA(A) receptor. Model 1 is based on the 4-A resolution structure of the nicotinic acetylcholine receptor from Torpedo marmorata and represents the unliganded receptor. Two agonists, GABA and muscimol, two benzodiazepines, flunitrazepam and alprazolam, together with the general anaesthetic halothane, have been docked to this model. The ion flow is also explored in model 1 by evaluating the interaction energy of a chloride ion as it traverses the extra...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jmgm.2007.04.012
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- Journal:
- Journal of molecular graphics and modelling
- Volume:
- 26
- Issue:
- 4
- Pages:
- 760-774
- Publication date:
- 2007-11-05
- DOI:
- EISSN:
-
1873-4243
- ISSN:
-
1093-3263
- URN:
-
uuid:24d85e92-6e8d-4b63-832a-a549e35f0371
- Source identifiers:
-
154248
- Local pid:
- pubs:154248
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor.
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