Co-transcriptional commitment to alternative splice site selection.

Journal article

Production of mRNA in eukaryotic cells involves not only transcription but also various processing reactions such as splicing. Recent experiments have indicated that there are direct physical connections between components of the transcription and processing machinery, supporting previous suggestions that pre-mRNA splicing occurs co-transcriptionally. Here we have used a novel functional approach to demonstrate co-transcriptional regulation of alternative splicing. Exon 3 of the alpha-tropomy...

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Authors: Roberts, G; Gooding, C; Mak, H; Proudfoot, N; Smith, C

• Publication status: Published
• Journal: Nucleic acids research
• Volume: 26
• Issue: 24
• Pages: 5568-5572
• Publication date: 1998-12-01
• DOI: 10.1093/nar/26.24.5568
• EISSN: 1362-4962
• ISSN: 0305-1048
• Language: English
• Keywords: Tropomyosin; Humans; Alternative Splicing; Models, Molecular; Animals; RNA; Transcription, Genetic; Models, Genetic