Advanced glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells

Journal article

It is becoming apparent that diabetes results in the increased expression of angiogenic growth factors in numerous tissues as a response to both hyperglycemia and tissue ischemic. Angiogenesis is regulated by vascular growth factor, particularly the vascular endothelial growth family of proteins (VEGF). Glucose binds to protein amino residues and forms early glycation products such as Schiff base and Amadori products. The final Maillard reaction leading to the production of advanced glycation...

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Authors: Pertńaska-Marczewska, M; Feldmann, M; Paleolog, E

• Journal: Diabetologia Polska
• Volume: 10
• Issue: 4
• Pages: 375-380
• Publication date: 2003-01-01
• ISSN: 1233-4723
• Language: English
• Keywords: Diabetic vascular complications; Vascular endothelial growth factor (VEGF); THP-1 cell line