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Advanced glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells

Abstract:

It is becoming apparent that diabetes results in the increased expression of angiogenic growth factors in numerous tissues as a response to both hyperglycemia and tissue ischemic. Angiogenesis is regulated by vascular growth factor, particularly the vascular endothelial growth family of proteins (VEGF). Glucose binds to protein amino residues and forms early glycation products such as Schiff base and Amadori products. The final Maillard reaction leading to the production of advanced glycation...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Diabetologia Polska More from this journal
Volume:
10
Issue:
4
Pages:
375-380
Publication date:
2003-01-01
ISSN:
1233-4723
Language:
English
Keywords:
Pubs id:
pubs:225770
UUID:
uuid:24cc673a-6c49-4e13-b273-d6300151e803
Local pid:
pubs:225770
Source identifiers:
225770
Deposit date:
2012-12-19

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