Journal article icon

Journal article

Gas-stabilizing gold nanocones for acoustically mediated drug delivery

Abstract:

The efficient penetration of drugs into tumors is a major challenge that remains unmet. Reported herein is a strategy to promote extravasation and enhanced penetration using inertial cavitation initiated by focused ultrasound and cone-shaped gold nanoparticles that entrap gas nanobubbles. The cones are capable of initiating inertial cavitation under pressures and frequencies achievable with existing clinical ultrasound systems and of promoting extravasation and delivery of a model large thera...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/adhm.201800184

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
ORCID:
0000-0002-7399-7759
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
ORCID:
0000-0002-4882-1356
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Magdalen College
Role:
Author
ORCID:
0000-0001-8792-7818
Expand authors...
Institution of Engineering and Technology More from this funder
Danish Council for Independent Research, Technology and Production Sciences More from this funder
Sapere Aude More from this funder
Publisher:
Wiley Publisher's website
Journal:
Advanced Healthcare Materials Journal website
Volume:
7
Issue:
12
Article number:
1800184
Publication date:
2018-04-25
Acceptance date:
2018-03-15
DOI:
EISSN:
2192-2659
ISSN:
2192-2640
Pmid:
29696808
Source identifiers:
846008
Language:
English
Keywords:
Pubs id:
pubs:846008
UUID:
uuid:24c852e6-a85b-4bc3-b511-39fb881b42dd
Local pid:
pubs:846008
Deposit date:
2018-05-31

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP