Journal article
The maternal brain: Region‐specific patterns of brain aging are traceable decades after childbirth
- Abstract:
- Pregnancy involves maternal brain adaptations, but little is known about how parity influences women's brain aging trajectories later in life. In this study, we replicated previous findings showing less apparent brain aging in women with a history of childbirths, and identified regional brain aging patterns linked to parity in 19,787 middle‐ and older‐aged women. Using novel applications of brain‐age prediction methods, we found that a higher number of previous childbirths were linked to less apparent brain aging in striatal and limbic regions. The strongest effect was found in the accumbens—a key region in the mesolimbic reward system, which plays an important role in maternal behavior. While only prospective longitudinal studies would be conclusive, our findings indicate that subcortical brain modulations during pregnancy and postpartum may be traceable decades after childbirth.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1002/hbm.25152
Authors
- Publisher:
- Wiley
- Journal:
- Human Brain Mapping More from this journal
- Volume:
- 41
- Issue:
- 16
- Pages:
- 4718-4729
- Article number:
- 25152
- Publication date:
- 2020-08-07
- Acceptance date:
- 2020-07-16
- DOI:
- EISSN:
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1097-0193
- ISSN:
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1065-9471
- Language:
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English
- Keywords:
- Pubs id:
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1119271
- Local pid:
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pubs:1119271
- Deposit date:
-
2020-07-16
Terms of use
- Copyright holder:
- de Lange et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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