Population dynamics of HIV-2 in rural West Africa: Comparison with HIV-1 and ongoing transmission at the heart of the epidemic

De Silva, T; De Silva, T; De Silva, T; Van Tienen, C; Van Tienen, C; Onyango, C; Jabang, A; Vincent, T; Vincent, T; Van Der Loeff, M; Coutinho, R; Jaye, A; Rowland-Jones, S; Whittle, H; Whittle, H; Cotten, M; Cotten, M; Hué, S

Journal article

Population dynamics of HIV-2 in rural West Africa: Comparison with HIV-1 and ongoing transmission at the heart of the epidemic

Abstract:: Objectives: To compare the population dynamics of HIV-2 and HIV-1, and to characterize ongoing HIV-2 transmission in rural Guinea-Bissau. Design: Phylogenetic and phylodynamic analyses using HIV-2 gag and env, and HIV-1 env sequences, combined with epidemiological data from a community cohort. Design: Samples were obtained from surveys in 1989-1991, 1996-1997, 2003 and 2006-2007. Phylogenies were reconstructed using sequences from 103 HIV-2-infected and 56 HIV-1-infected patients using Bayesian Evolutionary Analysis by Sampling Trees (BEAST), a relaxed molecular clock and a Bayesian skyline coalescent model. Results: Bayesian skyline plots showed a strong increase in the 1990s of the HIV-1 effective population size (Ne) in the same period that the Ne of HIV-2 came into a plateau phase. The population dynamics of both viruses were remarkably similar following initial introduction. Incident infections were found more often in HIV-2 transmission clusters, with 55-58% of all individuals contributing to ongoing transmission. Some phylogenetically linked sexual partners had discordant viral loads (undetectable vs. detectable), suggesting host factors dictate the risk of disease progression in HIV-2. Multiple HIV-2 introductions into the cohort are evident, but ongoing transmission has occurred predominantly within the community. Conclusion: Comparison of HIV-1 and HIV-2 phylodynamics in the same community suggests both viruses followed similar growth patterns following introduction, and is consistent with the hypothesis that HIV-1 may have played a role in the decline of HIV-2 via competitive exclusion. The source of ongoing HIV-2 transmission in the cohort appears to be new HIV-2 cases, rather than the pool of older infections established during the early growth of HIV-2. © 2012 Wolters Kluwer Health | Lippincott Williams and Wilkins.

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

De Silva, T., De Silva, T., De Silva, T., Van Tienen, C., Van Tienen, C., Onyango, C., Jabang, A., Vincent, T., Vincent, T., Van Der Loeff, M., Coutinho, R., Jaye, A., Rowland-Jones, S., Whittle, H., Whittle, H., Cotten, M., Cotten, M., & Hué, S. (2013). Population dynamics of HIV-2 in rural West Africa: Comparison with HIV-1 and ongoing transmission at the heart of the epidemic. AIDS, 27(1), 125–134.

MLA Style

De Silva, T, et al. “Population Dynamics of HIV-2 in Rural West Africa: Comparison with HIV-1 and Ongoing Transmission at the Heart of the Epidemic.” AIDS, vol. 27, no. 1, 2013, pp. 125–34.

Chicago Style

De Silva, T, T De Silva, T De Silva, et al. 2013. “Population Dynamics of HIV-2 in Rural West Africa: Comparison with HIV-1 and Ongoing Transmission at the Heart of the Epidemic.” AIDS 27 (1): 125–34.
Print