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Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.

Abstract:

The adhesion of Plasmodium falciparum-infected erythrocytes to human tissues or endothelium is central to the pathology caused by the parasite during malaria. It contributes to the avoidance of parasite clearance by the spleen and to the specific pathologies of cerebral and placental malaria. The PfEMP1 family of adhesive proteins is responsible for this sequestration by mediating interactions with diverse human ligands. In addition, as the primary targets of acquired, protective immunity, th...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m112.416347

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Journal:
The Journal of biological chemistry
Volume:
288
Issue:
8
Pages:
5992-6003
Publication date:
2013-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:24c24918-ce83-44b7-9139-d071b5ff43a1
Source identifiers:
374292
Local pid:
pubs:374292

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