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Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice.

Abstract:

Thiamine (vitamin B1) deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)-3β. While decreased GSK-3β activity appears to impair memory, increased GSK-3β activity is associated with the distressed/depressed state. However, hitherto direct evidence for the effects of thiamine on GSK-3...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.pnpbp.2016.11.001

Authors


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Institution:
University of Oxford
Oxford college:
Somerville College
Role:
Author
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Name:
Seventh Framework Programme
Grant:
602805
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Name:
Belgian Funds for Scientific Research
Publisher:
Elsevier
Journal:
Progress in Neuro-Psychopharmacology and Biological Psychiatry More from this journal
Volume:
75
Pages:
148-156
Publication date:
2016-11-01
Acceptance date:
2016-11-03
DOI:
EISSN:
1878-4216
ISSN:
0278-5846
Language:
English
Keywords:
Pubs id:
pubs:659518
UUID:
uuid:24a1b15b-dae6-4f70-a2c6-802d5dac95d8
Local pid:
pubs:659518
Source identifiers:
659518
Deposit date:
2016-12-29

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