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Journal article

Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis

Abstract:

Focal lesions and brain atrophy are the most extensively studied aspects of multiple sclerosis (MS), but the image acquisition and analysis techniques used can be further improved, especially those for studying within-patient changes of lesion load and atrophy longitudinally. Improved accuracy and sensitivity will reduce the numbers of patients required to detect a given treatment effect in a trial, and ultimately, will allow reliable characterization of individual patients for personalized t...

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Publisher copy:
10.1007/s00415-012-6762-5

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Journal of Neurology
Volume:
260
Issue:
10
Pages:
2458-2471
Publication date:
2013-10-05
DOI:
EISSN:
1432-1459
ISSN:
0340-5354
URN:
uuid:24947802-14c1-435d-a757-35fae12ab820
Source identifiers:
436290
Local pid:
pubs:436290

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