Journal article : Review
The role of potentiating mutations in the evolution of pandemic Escherichia coli clones
- Abstract:
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The Escherichia coli species exhibits a vast array of variable lifestyles, including environmental, commensal, and pathogenic organisms. Many of these E. coli contribute significantly to the global threat of antimicrobial resistance (AMR). Multidrug-resistant (MDR) clones of E. coli have arisen multiple times over varying timescales. The repeated emergence of successful pandemic clones, including the notorious ST131 lineage, highlights a desperate need to further study the evolutionary processes underlying their emergence and success. Here, we review the evolutionary emergence of E. coli ST131 pandemic clones and draw parallels between their evolutionary trajectories and those of other lineages. From colonization and expansion to the acquisition of multidrug resistance plasmids, potentiating mutations are present at each stage, leading to a proposed sequence of events that may result in the formation of an antimicrobial-resistant pandemic clone.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 946.7KB, Terms of use)
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- Publisher copy:
- 10.1007/s10096-021-04359-3
Authors
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 108876B15Z
- Publisher:
- Springer Nature
- Journal:
- European Journal of Clinical Microbiology and Infectious Diseases More from this journal
- Publication date:
- 2021-11-17
- Acceptance date:
- 2021-09-30
- DOI:
- EISSN:
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1435-4373
- ISSN:
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0934-9723
- Pmid:
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34787747
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1544079
- Local pid:
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pubs:1544079
- Deposit date:
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2025-04-30
- ARK identifier:
Terms of use
- Copyright holder:
- Cummins et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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