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Disorders of the calcium-sensing receptor.

Abstract:

The human calcium-sensing receptor (CaSR) is a 1078-amino-acid cell surface protein which is expressed in the parathyroids, thyroid cells and the kidney, and is a member of the family of G protein-coupled receptors. The CaSR allows regulation of parathyroid hormone (PTH) secretion and renal tubular calcium reabsorption in response to alterations in extracellular calcium concentrations. The human CaSR gene is located on chromosome 3q13.3-q21, and loss of function CaSR mutations have been repor...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Volume:
1448
Issue:
2
Pages:
166-170
Publication date:
1998-12-05
DOI:
ISSN:
0006-3002
URN:
uuid:248b7507-3909-4a2f-9017-ff030e04b6db
Source identifiers:
20027
Local pid:
pubs:20027

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