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Disorders of the calcium-sensing receptor.

Abstract:

The human calcium-sensing receptor (CaSR) is a 1078-amino-acid cell surface protein which is expressed in the parathyroids, thyroid cells and the kidney, and is a member of the family of G protein-coupled receptors. The CaSR allows regulation of parathyroid hormone (PTH) secretion and renal tubular calcium reabsorption in response to alterations in extracellular calcium concentrations. The human CaSR gene is located on chromosome 3q13.3-q21, and loss of function CaSR mutations have been repor...

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Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1448
Issue:
2
Pages:
166-170
Publication date:
1998-12-01
Event title:
5th European Symposium on Calcium Binding Proteins in Normal and Transformed Cells
DOI:
ISSN:
0006-3002
Source identifiers:
20027
Keywords:
Pubs id:
pubs:20027
UUID:
uuid:248b7507-3909-4a2f-9017-ff030e04b6db
Local pid:
pubs:20027
Deposit date:
2012-12-19

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